The variations of epidermic and chemical components in ginseng rust rot caused by Cylindrocarpon destructans,biological characters and molecular biology of the pathogen and disease control were summarized in this review.It showed that total saponin,rough amylum and total sugar decreased while lignin,fatty acid and reducing sugar increased.The content of Ca,Zn,Mn,Fe, Al and Si increased but the content of K decreased.The researches in biological characters were made on the optimum conditions for the pathogen,such as carbon source,nitrogen source,pH,etc.The effects of Fe,Pd,Zn,Cd and Cu to mycelium growth were also concluded.The agricultural control and biological control of the disease were summarized.Rotation and organic fertilizer application were the proper methods of agricultural control.The biological control was focused on the selection of antagonism.The latter method of controlling ginseng rust rot will have a bright future.