Study on the relationship between gallbladder cholesterol polyps and the pathogenesis of gallstones

Objective To study on the relationship between gallbladder cholesterol polyps and the pathogenesis of gallstone.Methods gallbladder stone,bile and part of gallbladder full-thickness tissue were collected from 62 patients who underwent laparoscopic cholecystectomy from April 2008 to september 2008 in our center,including 31 patients with gallbladder cholesterol polyps,18 patients with cholesterol gallstones and 13 patients in control(6 patients with gallbladder adenoma and 7 patients with non-cholesterol gallstone).sonography was applied to measure the gallbladder three diameter before and 1 hour after breakfast to evaluate the contracted function of gallbladder.The contents of cholesterol in gallstone and cholesterol,bile acid and phospholipid in bile were measured,and the full-thickness tissue of the gallbladder wall was done the pathological examination.Results Emptying Rate of Gallbladder in the patients with cholesterol polyps was(47.3±18.6)%,it was significantly decreased comparing with those that in the healthy people(71.7±8.1)%,P0.01,but there ware no differences between the patients in group of cholesterol polyps and in group of gallstones(47.6±23.7)%.Cholesterol saturation index was higher in the patients with cholesterol polyps comparing with those that in control group(1.0±0.2 vs 0.6±0.3,P0.01),but there ware no differences between the patients in group of cholesterol polyps and in group of gallstones(1.0±0.2 vs1.0±0.2,P0.05).Gallstones and cholesterol polyps coexistence in 13 patients among 31 patients who with the gallbladder cholesterol polyps,and the incidence of gallstone is 41.9%.Conclusion the existence of gallbladder cholesterol polyps may lead to the formation of gallbladder stone.