The Clinical Importance to LVRM of Persistent Elevation of Electrocardiographic ST Segment and BNP Concentration in Acute Myocardial Infarction Patients after Primary PCI Therapy

Objective To investigate the outcome prediction of BNP and ST segment to LV remodeling(LVRM) by observing the relation of the changes of ST segment in electrocardiograms and plasma BNP in cases with AMI after PCI operation with LVRM.Methods Forty-eight patients with a first AMI treated with primary PCI were selected.The extent of the ST segment elevation and resolution in electrocardiograms on admission and one hour after PCI was analyzed.All the patients were divided into two groups according to the extent of ST segment elevation and resolution.Group A:resolution of ST segment elevation≧50%,n=37;Group B:resolution of ST segments elevation50%,n=11;Plasma BNP levels was measured with eletrochemistry luminescent technique before PCI and at 7 days after PCI;echocardiogram was checked at 2～3 days and 3 months after AMI.Results With PCI treatment,the plasma BNP levels in group A decreased significantly vs in group B;in group A,the plasma BNP levels after treatment decreased significantly vs before treatment;on the contrary in group B.In group A,there was no significant difference of LVEDD between at 2～3 days after PCI and at 3 months after PCI;in group B,LVEDD at 3 months after PCI increased significantly vs that at 2～3 days after PCI;the rate of LVRM in group B was bigger than that in group A.Conclusion The persist elevation of ST segment and the plasma BNP levels after PCI in AMI patien is clinically important for predicting the LVRM.