THE STUDY OF MULTI-ARMED INTERIM ANALYSIS IN CLINCAL TRIALS.

Objective:To introduce the multi-armed interim analysis methods in clinical trials.Methods:Based on multi-armed analysis methods,extend the two-group group sequential interim analysis methods to multi-armed interim analysis.Results:Multi-armed interim analysis include the global test and pair-wise tests of all groups.Conclusion:The boundary for interim analysis is the key of multi-armed interim analysis.