Role of reactive oxygen species in cervical carcinoma

Reactive oxygen species(ROS) are generated from the metabolism of aerobic cells.The over accumulation of ROS could lead to oxidative stress,which may cause cellular damage.Meanwhile,there exists an anti-oxidative stress system in the body to protect cells from oxidative injury.With more evidence revealed from recent studies,the role of ROS in the formation of human cancer has been well established.Imbalance of the pro-and anti-oxidative stress system might be the key factor of tumorigeness.Cervical carcinoma is a common malignant tumor in women worldwide,whereas the mechanisms underlying its development is still unknown.Recently,the role of ROS in human cervical carcinoma has been attracted attention in clinical or in vitro study.