Pachymic acid targets PDIA6 to delay mesenchymal stem cell senescence through the G6PD/STAT3 signaling axis and prevent senile osteoporosis

These findings elucidate that PA specifically targets PDIA6, alleviating PDIA6-mediated inhibition of G6PD and activating the G6PD/STAT3 signaling axis to counteract hMSC senescence. PA ameliorates SOP by delaying BMSC senescence through this conserved mechanism.