Associations of Chronic Rhinosinusitis and Nasal Polyps With Elevated Venous Thromboembolism Risk: Evidence From the UK Biobank

The data that support the findings of this study are available from UK Biobank. Restrictions apply to the availability of these data, which were used under license for this study. Data are available from https://www.ukbiobank.ac.uk/ with the permission of UK Biobank. Figure S1: Sensitivity analyses for the associations of CRS and NP with VTE, DVT, and PE. The associations between exposures (CRS or NP) and thrombotic outcomes remained robust across multiple sensitivity settings. (A) Follow-up truncated at 10 years; (B) 5-year landmark analysis; (C) additional adjustment for baseline corticosteroid use; (D) exclusion of participants with a history of cancer; (E) mutually exclusive diagnoses (CRSwNP and CRSsNP) as exposures; (F) hospital-inpatient main diagnosis as outcomes. Figure S2: Stratified analyses of exposures (CRS or NP) with DVT risk according to Townsend index, asthma, PRS for VTE, and blood eosinophil count. Figure S3: MR analyses evaluating causal effects of self-reported NP and NP surgery on DVT and inpatient-diagnosed thrombophlebitis (I80, I80.2) using the IVW method. Table S1: Participants' characteristics stratified by the presence of CRS and NP at baseline. Table S2: Risk of systemic diseases among individuals with chronic rhinosinusitis or nasal polyps. Table S3: Complete results of Mendelian randomization analyses. Table S4: Associations of CRS and NP with blood inflammatory markers. Table S5: Associations of inflammatory biomarkers with incident deep vein thrombosis. Table S6: Mediation effects of selected inflammatory markers in the associations between exposures (CRS or NP) and DVT. Table S7: ICD-10 codes for identification of systemic outcomes. Table S8: Diagnostic codes for venous thromboembolism. Table S9: Definitions of covariates. Table S10: OpenGWAS datasets used for Mendelian randomization analyses. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.