高内皮静脉
CCL21型
CXCL13型
生发中心
甲状腺
C-C趋化因子受体7型
生物
趋化因子
淋巴细胞
淋巴系统
免疫学
病理
细胞生物学
B细胞
医学
内分泌学
炎症
趋化因子受体
抗体
作者
Andrea E. Martin,Elizabeth C. Coronel,Gen Ichiro Sano,Shu Chen,Galya Vassileva,Claudia Canasto-Chibuque,Jonathon D. Sedgwick,Paul S. Frenette,Martin Lipp,Glaucia C. Furtado,Sergio A. Lira
出处
期刊:Journal of Immunology
[American Association of Immunologists]
日期:2004-10-15
卷期号:173 (8): 4791-4798
被引量:80
标识
DOI:10.4049/jimmunol.173.8.4791
摘要
Abstract Lymphocytic infiltrates and lymphoid follicles with germinal centers are often detected in autoimmune thyroid disease (AITD), but the mechanisms underlying lymphocyte entry and organization in the thyroid remain unknown. We tested the hypothesis that CCL21, a chemokine that regulates homeostatic lymphocyte trafficking, and whose expression has been detected in AITD, is involved in the migration of lymphocytes to the thyroid. We show that transgenic mice expressing CCL21 from the thyroglobulin promoter (TGCCL21 mice) have significant lymphocytic infiltrates, which are topologically segregated into B and T cell areas. Although high endothelial venules expressing peripheral lymph node addressin were frequently observed in the thyroid tissue, lymphocyte recruitment was independent of L-selectin or lymphotoxin-α but required CCR7 expression. Taken together, these results indicate that CCL21 is sufficient to drive lymphocyte recruitment to the thyroid, suggest that CCL21 is involved in AITD pathogenesis, and establish TGCCL21 transgenic mice as a novel model to study the formation and function of lymphoid follicles in the thyroid.
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