废止
化学
嘧啶
药物化学
组合化学
有机化学
催化作用
碳纤维
立体化学
复合数
复合材料
材料科学
作者
Zemin Qin,Yongmin Ma,Fanzhu Li
标识
DOI:10.1021/acs.joc.1c01847
摘要
An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed. It involves a [3 + 2 + 1] three-component annulation of amidines, ketones, and one carbon source. N,N-Dimethylaminoethanol is oxidized through C(sp3)-H activation to provide the carbon donor. One C-C and two C-N bonds are formed during the oxidative annulation process. The reaction shows good tolerance to many important functional groups in air, making this methodology a highly versatile alternative, and significant improvement to the existing methods for structuring a pyrimidine framework, especially 4-aliphatic pyrimidines.
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