分离(微生物学)
肽
生物利用度
药理学
癌症研究
化学
计算生物学
医学
生物
生物化学
生物信息学
作者
Eric Savier,Pierre Tufféry,Heriberto Bruzzoni‐Giovanelli,Angelita Rebollo
出处
期刊:Methods in molecular biology
日期:2021-11-12
卷期号:: 413-427
被引量:1
标识
DOI:10.1007/978-1-0716-1752-6_26
摘要
Methods for isolation of human primary cells is an important tool to be able to test the effect of several drugs for the treatment of diseases. Protocols have been described for the isolation of healthy and tumoral hepatocytes; however, the quality and the amount of the isolated cells is not satisfactory. We describe here protocols for the isolation of healthy and tumoral hepatocytes as well as the use of tumor penetrating and interfering peptides as new therapeutics. Peptides are showed to be safe drugs and taking into account recent improvements in peptide administration, biodelivery, and bioavailability. Tumor penetrating peptides fused to an interfering peptide have a great potential to become therapeutic agents.
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