化学
环肽
生物活性
抗菌剂
驱虫药
立体化学
铜绿假单胞菌
肽
抗菌活性
假单胞菌科
细菌
生物化学
体外
有机化学
生物
遗传学
生态学
作者
Boja Poojary,S. L. Belagali
标识
DOI:10.1016/j.ejmech.2004.11.013
摘要
Two biologically active cyclic peptides, Yunnanin F 8 and Hymenistatin 16 were synthesized and the structures were established on the basis of analytical, IR, NMR and mass spectral data. The newly synthesized compounds were screened for their antimicrobial and pharmacological activities. These cyclic octapeptides have shown moderate to good growth inhibition against bacterial strains and weak activity against fungal strains more than that of the standard drug against only Pseudomonas aeruginosa but weak to moderate activity against remaining three bacterial strains. They have shown very weak activity against fungal strains. Yunnanin F possessed good anthelmintic activity while Hymenistatin possessed very low activity, but both showed moderate anti-inflammatory activity.
科研通智能强力驱动
Strongly Powered by AbleSci AI