氧化应激
化学
纳米技术
抗氧化剂
过氧化物酶
酶
材料科学
生物化学
作者
Majid Sharifi,Kousar Faryabi,Amir Jouya Talaei,Mudhir Sabir Shekha,Mahsa Ale-Ebrahim,Abbas Salihi,Nadir Mustafa Qadir Nanakali,Falah Mohammad Aziz,Behnam Rasti,Anwarul Hasan,Mojtaba Falahati
标识
DOI:10.1016/j.molliq.2019.112004
摘要
AuNPs with enzyme-like features have received strong attention in different areas, although limited data is available in literature on their biological/industrial functions. NPs especially Au counterparts have been shown to functionally mimic the activity of antioxidant enzyme. Indeed, due to low cytotoxicity and SPR characteristics of AuNPs, there are a great number of reports in which Au nanozymes yield promising responses in biomedical applications. In this review, we aim to overview the enzymatic activity of Au nanozymes along with their regulatory and controlling mechanisms. We have reviewed the effect of various factors such as dimension, morphology, functionalization and presence of hybrid materials on the catalytic activity of Au nanozymes as well as a detail survey on the oxidase, peroxidase, SOD, and CAT-like activities of Au nanozyme. Finally, the significance of Au nanozymes in mitigating oxidative stress followed by conclusion and challenges were reported. Based on this paper, we envision that Au nanozymes can be used as a promising material to prevent oxidative stress-stimulated disorders.
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