Some studies of women’s health show that the risk of overweight, obesity and non-communicable chronic diseases often appear in middle-aged, instead of maintaining the right weight, many women suffer obesity in this age group. Therefore, this study was conducted to determine the prevalence of overweight, obesity and related factors among women aged 40-59 years in Cang Long district, Tra Vinh province. The study uses multivariate analysis and descriptive methods for cross-sectional data of 531 women. The results of overweight and obesity are 26.7% and 4.3% respectively. The study found a statistically significant correlation between overweight and obesity with a number of factors. To be specific, women with higher education levels have the lower rate of overweight and obesity (p <0,01) and family history is also related to overweight and obesity (p <0,001), while the use of ≥ 4 units/day (abuse) will increase the higher rate of overweight and obesity than the group use less/no (p <0,001). The consumption of fruits ≥ 3 units/day has the rate of overweight, obesity higher than the consumption group < 2 units (p= 0,02). The group of women who have regular physical activity with moderate intensity has lower ratio of overweight, obesity than the irregular group (p= 0,006).