Определение действующего вещества в лекарственной форме для лечения воспалительных заболеваний пародонта

For today, inflammatory periodontium diseases has high prevalence among the population all over the world (80 %), the given pathology meets at 95 % of the population in our country. Thus medical products can be more effective and often compete to other medicinal forms. The particular interest is given to local therapeutic systems which provide prolonged actions on the inflammation centre periodontial fabrics. Depending on structure of the medicinal form and a way of its reception, between medicinal and auxiliary substances there can be various interactions to formation of complexes that in turn can raise or lower solubility, absorption operating substances, influences a choice of a method of quantitative definition of operating substance in the given medicinal form etc. One of the important sections at creation of the medicinal form is working out of methods of quantitative definition of operating substances. Except titrimetric methods of a quantitative estimation of operating substance as a part of the medicinal form, physical and chemical methods of the analysis, are characterized by high sensitivity and selectivity now are developed and used. The purpose of the present work is working out of a technique of quantitative definition of metronidazole in the modelling medicinal form in the form of a stomatologic pin a method ultra-violet spectrophotometry. It is established that at absorption metronidasol in a spectrum Uf-part, an absorption strip at λ =310±2 the nanometer, caused by presence is observed an absorption strip at λ =310±2 the nanometer, caused by presence π→ π * and n → π * electronic transitions that will be co-ordinated with the literary data. Objects of research were the medical stomatologic pins developed for treatment of inflammatory periodontium diseases. The structure and a way of reception is protected by the patent of the Russian Federation. Studied DSP consist of 1 part of metronidazole and 9 parts of a copolymer of styrene with maleic anhydride. Uf-spectra removed on spectrophotometerе Council of Federation-46 in a range of lengths of waves 210-350±2 nanometer, in quality extractant used isopropyl spirit. Removal of spectra was spent right after by preparations of solutions. The range of concentration in which it is observed to the law of Bugera-Lamberta-Bera is established. The preliminary Uf-spectrum isopropyl extraction DSP with metronidazole is characterised by presence ill-defined a maximum at 310 nanometers and a minimum at 265 nanometers. It is constructed the calibrating diagram for an interval of concentration with direct proportional dependence. The quantitative maintenance of operating substance defined Uf-spektrofotometrical method of standards. The experimental found quantity of a substance in modelling mixes corresponded preliminary calculated, taking into account an error of the device and an admissible error of a method. Thus, the technique of Uf-spektrofotometrical quantitative definition of metronidazole in medical stomatologic pins is developed.