Synthesis and structure of new carbohydrate metal–organic frameworks and inclusion complexes

Two new metal–organic framework compounds based on natural β-cyclodextrin molecules (β-CD) and alkali metals (Na+/K+) were synthesized and characterized by elemental analyses, IR, XPRD and 1HNMR. Single-crystal X-ray diffraction analysis reveals that compounds 1 and 2 possess the bowl-like pore and the “8” type double channels configuration. Due to the [blow + channel] double configuration, 5-Fluorouracil (5-FU) and Quercetin inclusion complexes of compound 1 are studied, and the results show that the two kinds of drug with different structure and size can be included into the compound at the same time, which is expected to become a new type of multi-functional green crystalline solid material.