化学
粘度
荧光
生物物理学
活性氧
次氯酸
光化学
次氯酸盐
氧化应激
生物化学
有机化学
量子力学
生物
物理
作者
Xiangyong Huang,Tao Luo,Chuang Zhang,Junrong Li,Zejin Jia,Xulang Chen,Yanjun Hu,Hong Huang
出处
期刊:Talanta
[Elsevier]
日期:2022-05-01
卷期号:241: 123235-123235
被引量:16
标识
DOI:10.1016/j.talanta.2022.123235
摘要
Viscous microenvironments are ubiquitous in living organisms. An oxidative stress attack could cause the fluctuation of lymph or blood viscosity, which is closely related to many common diseases. However, the dual-function detection of reactive oxygen species and viscosity is still ineffective due to design defects. Herein, by rational linking a propeller-shaped triphenylamine rotator and a rigid planar anthracene, we report the first dual-ratiometric-response probe for ClO- and viscosity detection. The probe itself shows weak fluorescence background in low-viscous solution or at non-aggregate state, which can largely switch on its blue (414 nm) and yellow fluorescence (600 nm) respectively in response to ClO- and viscosity. Their sensing mechanisms were elucidated through the interruption of FRET and TICT processes for ClO- and viscosity detection, respectively. In addition to its mitochondria targeting ability, TPP-AN was employed for mitochondrial viscosity and ClO- imaging in HeLa cells, providing a potentially useful probe for clinical assays.
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