骨整合
材料科学
结晶度
钛
X射线光电子能谱
钡
接触角
生物医学工程
化学工程
植入
复合材料
外科
医学
冶金
工程类
作者
Jielong Zhou,Linjia Jian,Jianjiang Xie,Shi Cheng,Baoe Li,Donghui Wang,Hongwei Shao,Yu Zhang,Feng Peng
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2022-02-10
卷期号:8 (3): 1271-1278
被引量:6
标识
DOI:10.1021/acsbiomaterials.1c01393
摘要
One of the major challenges for Ti-based implants is insufficient osteointegration, which might result in the loosening of the implant. In this study, we fabricated strontium (Sr)-containing barium titanate (BST) on the surface of Ti to improve the bioactivity for osteointegration enhancement. The introduction of Sr significantly reduced the crystallization time and improved crystallinity, which was proved by X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. Compared with Ti, the BST film showed greater wettability surface and lower elastic modulus and hardness. Furthermore, in synergy with the release of Sr ions, the BST film improved early adhesion and followed osteogenic differentiation of rat bone mesenchymal stem cells. Furthermore, the bone implantation experiment suggested that the BST film could significantly improve the in vivo osteogenesis and osteointegration capabilities of Ti implants. In summary, this study revealed that BST-modified Ti has potential application in bone repair.
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