Electrochemiluminescence metal-organic frameworks biosensing materials for detecting cancer biomarkers

Early detection of severe diseases like cancer is an urgent need for public health and safety. It can determine by using synthesized materials for sensing cancer biomarkers. Electrochemiluminescence (ECL) sensing of cancer biomarkers is getting much more attention these days. Metal-organic frameworks (MOFs) show excellent ECL properties and are getting much attention for sensing cancer biomarkers. The functionalities present and tunable structure of MOFs provide a great sensing platform. This review summarizes the mechanistic study of detecting cancer biomarkers using MOF materials. Compelling goals such as efficiency, fabrication of MOFs, immobilization or encapsulation by nanoparticles, organic or inorganic lumiphores, and detection range and limit have been studied and described well. • Signal amplification principle and working of electrochemiluminescence (ECL). • Metal-organic frameworks (MOFs) materials as ECL biosensors to detect cancer biomarkers. • Encapsulation of NPs, inorganic and organic luminophores as ECL enhancers. • Challenges and future trends in MOF as ECL biosensors.