单线态氧
化学
光动力疗法
酞菁
光热治疗
缺氧(环境)
生物物理学
癌症研究
氧气
光化学
纳米技术
有机化学
材料科学
生物
作者
Yuanyuan Zhao,Ling Zhang,Zixuan Chen,Biyuan Zheng,Mei‐Rong Ke,Xingshu Li,Jian‐Dong Huang
摘要
Most photodynamic therapy (PDT) paradigms work through the highly O2-dependent type II photoreaction to generate singlet oxygen (1O2). The hypoxic microenvironment of solid tumors severely hampers therapeutic outcomes. Here, we present a novel design that could transfer the photophysical and photochemical properties of traditional phthalocyanine-based photosensitizers from type II photoreaction to efficient type I photoreaction and vibrational relaxation-induced photothermal conversion. These features enable the obtained nanostructured phthalocyanine assemblies (e.g., NanoPcAF) to display excellent phototherapies under both normoxic and hypoxic conditions. Moreover, NanoPcAF has a high level of accumulation in tumor tissues after intravenous injection, and 94% of tumor growth is inhibited in a preclinical model at a NanoPcAF dose of 0.8 nmol g-1 and light dose of 300 J cm-2.
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