医学
行动方式
临床试验
药理学
重症监护医学
血压
生物信息学
传统医学
内科学
生物
毒理
作者
Matteo Micucci,Cristiano Bolchi,Roberta Budriesi,Monica Cevenini,Lorenzo Maroni,S. Capozza,Alberto Chiarini,Marco Pallavicini,Andrea Angeletti
出处
期刊:Phytochemistry
[Elsevier]
日期:2020-02-01
卷期号:170: 112222-112222
被引量:11
标识
DOI:10.1016/j.phytochem.2019.112222
摘要
Hypertension has become the leading risk factor for worldwide cardiovascular diseases. Conventional pharmacological treatment, after both dietary and lifestyle changes, is generally proposed. In this review, we present the antihypertensive properties of phytocomplexes from thirteen plants, long ago widely employed in ethnomedicines and, in recent years, increasingly evaluated for their activity in vitro and in vivo, also in humans, in comparison with synthetic drugs acting on the same systems. Here, we focus on the demonstrated or proposed mechanisms of action of such phytocomplexes and of their constituents proven to exert cardiovascular effects. Almost seventy phytochemicals are described and scientifically sound pertinent literature, published up to now, is summarized. The review emphasizes the therapeutic potential of these natural substances in the treatment of the 'high normal blood pressure' or 'stage 1 hypertension', so-named according to the most recent European and U.S. guidelines, and as a supplementation in more advanced stages of hypertension, however needing further validation by clinical trial intensification.
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