清脆的
核酸酶
自愈水凝胶
DNA
纳米技术
基因组编辑
化学
计算生物学
计算机科学
材料科学
基因
生物
生物化学
有机化学
作者
Max A English,Luis R. Soenksen,Raphael V. Gayet,Helena de Puig,Nicolaas M. Angenent-Mari,Angelo S. Mao,Peter Q. Nguyen,James J. Collins
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-08-23
卷期号:365 (6455): 780-785
被引量:210
标识
DOI:10.1126/science.aaw5122
摘要
A CRISPR set of materials CRISPR technology is best known as a gene editing tool. English et al. developed a group of stimuli-responsive hydrogels to respond to the programmable nuclease Cas12a (see the Perspective by Han et al. ). The materials undergo molecular to macroscopic changes after Cas12a-dependent cleavage of double- or single-stranded DNA integrated into the gel. The authors show controlled release of particles linked to or imprisoned within the DNA, degradation of a gel with DNA solely forming the cross-links, and permeabilization of a gel with DNA partially forming the cross-links. These tools allow for the production of materials that release encapsulated nanoparticles and cells, act as degradable fuses, and enable remote radio-frequency identification signaling. Science , this issue p. 780 ; see also p. 754
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