生物
效应器
转录因子
抄写(语言学)
遗传学
细菌
细菌转录
DNA
功能(生物学)
基因
计算生物学
细胞生物学
基因表达
发起人
语言学
哲学
作者
Guo Fang Liu,Xin Xin Wang,Huidong Su,Guang Tao Lu
标识
DOI:10.16288/j.yczz.20-245
摘要
In bacteria, GntR family transcription regulators are the widespread family of transcription factors. Members of this family consist of two functional domains, a conserved N-terminal DNA-binding domain that contains a typical helix-turn-helix (HTH) motif and a C-terminal effector-binding or oligomerization domain. Usually, the amino acid sequences of N-terminal DNA-binding domains are highly conserved, but differ in the C-terminal effector-binding or oligomerization domains. In the past several decades, many GntR family transcription regulators have been characterized in a number of bacteria. These regulators control a variety of cellular processes such as cell motility, glucose metabolism, bacterial resistance, pathogenesis and virulence. In this review, we summarized the discovery, C-terminal domains, biological function and regulation mode of GntR family transcription regulators. This review will help researchers to obtain more knowledge about the functions and mechanisms of the GntR family transcriptional regulatory factors.
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