自愈水凝胶
粘附
材料科学
体内
生物材料
泊洛沙姆
生物粘附
椎板切除术
药物输送
医学
纳米技术
共聚物
高分子化学
聚合物
复合材料
生物技术
精神科
生物
脊髓
作者
Yan Wang,Lanlan Li,Yongchang Ma,Yong Tang,Zhao Yang,Zimeng Li,Wendan Pu,Xuan Wen,Xiaojuan Cao,Jiafei Chen,Wei Chen,Yue Zhou,Jianxiang Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2020-06-10
卷期号:14 (7): 8202-8219
被引量:53
标识
DOI:10.1021/acsnano.0c01658
摘要
Postoperative epidural adhesion remains a clinically challenging problem in spine surgery. Currently there are no effective and safe antifibrotic and antiadhesion biomaterials that have been specifically developed for this complication in clinical practice. Herein we designed and engineered an advanced antiadhesion hydrogel with multiple functionalities, including temperature-responsive gelation, self-healing, tissue adhesiveness, antioxidation, anti-inflammation, and antifibrosis. This multifunctional supramolecular hydrogel can be facilely constructed by integrating three functional modules, i.e., a thermosensitive triblock copolymer, poloxamer 407 (PX); a reactive oxygen species-eliminating and anti-inflammatory nanoparticle (TPCD NP); and an adhesion-enhancing compound, tannic acid (TA). The optimal formulation (PXNT) was hierarchically screened based on in vitro properties and in vivo activities. Therapeutically, local treatment with PXNT hydrogel effectively prevented epidural fibrosis and adhesion after laminectomy in both rats and rabbits. Of note, PXNT hydrogel showed more beneficial efficacy than different control thermosensitive hydrogels and a commercially available barrier product, Interceed. Mechanistically, PXNT hydrogel significantly attenuated local oxidative stress, inhibited inflammatory responses, and reduced fibrotic tissue formation. Moreover, treatment with PXNT hydrogel did not cause systemic adverse effects and neurological symptoms. Consequently, PXNT hydrogel is a highly promising biomaterial for preventing postlaminectomy epidural adhesion and adhesions after other surgeries.
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