前额叶皮质
海马旁回
静息状态功能磁共振成像
功能磁共振成像
神经科学
注意缺陷多动障碍
颞叶皮质
心理学
默认模式网络
大脑活动与冥想
血氧水平依赖性
皮质(解剖学)
颞叶
认知
精神科
脑电图
癫痫
作者
Wei Wang,Bin Hu,Zhijun Yao,Mike Jackson,Ruiyue Liu,Chuanjiang Liang
标识
DOI:10.1109/ijcnn.2013.6707011
摘要
In this study, the amplitude of low frequency (0.01-0.08Hz) fluctuation (ALFF) and functional connections were used to analyze blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) data for 57 children with attention deficit hyperactivity disorder (ADHD) and 59 healthy controls (HC) in a resting state. Compared with HC, the ADHD showed significantly altered neural activity in the prefrontal and temporal cortex. In ADHD, altered functional connections were observed mainly in prefrontal cortex, temporal cortex, default mode network (DMN) and parahippocampal gyrus (PHG). The abnormalities in prefrontal and temporal cortex might provide evidence to support that functional abnormalities are extended from the prefrontal cortex to the temporal cortex in ADHD. Additionally, dysfunction of the DMN and PHG could be related to the pathophysiological mechanisms of ADHD.
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