癌症研究
药物开发
医学
药品
癌细胞
阿霉素
癌症
计算生物学
中心性
作者
Imran Ali,Mohammad Nadeem Lone,Zeid A. ALOthman,Abdulrahman Al-Warthan,Mohd Marsin Sanagi
出处
期刊:Current Drug Targets
[Bentham Science]
日期:2015-05-31
卷期号:16 (7): 711-734
被引量:94
标识
DOI:10.2174/1389450116666150309115922
摘要
Cancer has been cursed for human beings for long time. Millions people lost their lives due to
cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late
stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer.
Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides,
some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic
moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic
nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring
and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds
have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances
in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds
have also been discussed. Finally, the suggestions for syntheses of effective, selective, fast and human friendly anticancer
agents are discussed into the different sections.
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