外部限制膜
眼科
医学
视网膜
视网膜
外层核层
视力
视网膜脱离
糖尿病性视网膜病变
黄斑水肿
光学相干断层摄影术
视网膜病变
视网膜色素上皮
生物
神经科学
作者
Akihito Uji,Tomoaki Murakami,Kazuaki Nishijima,Tadamichi Akagi,Takahiro Horii,Naoko Arakawa,Yuki Muraoka,Abdallah A. Ellabban,Nagahisa Yoshimura
标识
DOI:10.1016/j.ajo.2011.08.041
摘要
To determine if hyperreflective foci in the outer retina are associated with photoreceptor integrity and the logarithm of minimal angle of resolution (logMAR) visual acuity (VA) in patients with diabetic macular edema (DME).Retrospective, observational, cross-sectional study.Patients (n=76; 108 eyes) with clinically relevant macular edema and no serous retinal detachment were analyzed retrospectively. Spectral-domain optical coherence tomography (SD-OCT) images were obtained for all patients. We investigated the relationship between the hyperreflective foci in the outer retinal layers of the external limiting membrane (ELM) at the fovea and the photoreceptor integrity and VA.SD-OCT showed that 58 eyes (53.7%) had hyperreflective foci in the outer retinal layers, and 107 eyes (99.1%) had hyperreflective foci in the inner retinal layers. The logMAR VA was significantly (P<.0001) worse in eyes with hyperreflective foci in the outer retinal layers than in eyes without them (0.463±0.382 vs 0.127±0.206, respectively). Disruption of the ELM line on OCT was significantly (P<.0001, for both comparisons) associated with both hyperreflective foci in the outer retinal layers and poor logMAR VA. Disruption of the junction of the inner and outer segment line (IS/OS) also was related to hyperreflective foci in the outer retinal layers and poor logMAR VA (P<.0001 for both comparisons).The presence of hyperreflective foci in the outer retina is closely associated with a disrupted ELM and IS/OS line on SD-OCT images and decreased VA in DME.
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