多发性硬化
神经保护
中枢神经系统
生长因子
调节器
脱髓鞘病
胰岛素样生长因子
生物
神经科学
下调和上调
内科学
医学
免疫学
受体
生物化学
基因
作者
Daniel Chesik,Jacques De Keyser,Nadine Wilczak
标识
DOI:10.1016/j.cytogfr.2007.04.001
摘要
Insulin-like growth factors (IGFs) are indispensable peptide hormones for proper development of the central nervous system (CNS). Because IGF-1 exhibits neuroprotective and myelinogenetic effects, it possesses therapeutic potential in treating neurodegenerative demyelinating diseases such as multiple sclerosis (MS). However, IGF actions are largely dependant on high-affinity regulatory IGF binding proteins (IGFBPs), which are likely to interfere with therapeutic attempts at elevating IGF-1 levels in the CNS. In particular, IGFBP-2 plays a dominant role in IGF regulation in the CNS and is upregulated in several pathological conditions, including MS. The question remains as to whether IGFBPs should be considered "interfering" components of IGF treatment strategies or might possibly be utilized to clinical advantage. This review discusses our current understanding of biological functions of IGFBP-2 in the CNS and its implications in the demyelinating disease MS.
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