Scaffold Assembly of Collagen-Like Triple Helices at the C-Terminus

Here, we report the C-terminal scaffold assembly of triple helical collagen mimetics using a triserine lactone (TSL) scaffold. It was found that the TSL scaffold can promote the triple helix formation and enhance the thermal stability of the resulting collagen-like structures. Keywords: Scaffold-assembled collagen mimetics, Triserine lactone, Triple helix, Collagen, Circular dichroism, Thermal denaturation