CCL18型
转移
乳腺癌
癌症研究
癌症
细胞外基质
医学
趋化因子
生物
受体
内科学
细胞生物学
作者
Jingqi Chen,Yihong Yao,Chang Gong,Fang Yu,Shicheng Su,Jianing Chen,Bodu Liu,Hui Deng,Fengsong Wang,Gang Li,Herui Yao,Fengxi Su,Karen S. Anderson,Qiang Liu,Mark E. Ewen,Xuebiao Yao,Erwei Song
出处
期刊:Cancer Cell
[Elsevier]
日期:2011-04-01
卷期号:19 (4): 541-555
被引量:515
标识
DOI:10.1016/j.ccr.2011.02.006
摘要
Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival. CCL18 released by breast TAMs promotes the invasiveness of cancer cells by triggering integrin clustering and enhancing their adherence to extracellular matrix. Furthermore, we identify PITPNM3 as a functional receptor for CCL18 that mediates CCL18 effect and activates intracellular calcium signaling. CCL18 promotes the invasion and metastasis of breast cancer xenografts, whereas suppressing PITPNM3 abrogates these effects. These findings indicate that CCL18 derived from TAMs plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.
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