胶质瘤
自噬
细胞生长
蛋氨酸
胱氨酸
化学
谷胱甘肽
细胞生物学
癌症研究
体外
生物
半胱氨酸
生物化学
细胞凋亡
酶
氨基酸
作者
Huailei Liu,Weiguang Zhang,Kaikai Wang,Xiaoxiong Wang,Fei Yin,Chenguang Li,Chunlei Wang,Boxian Zhao,Zhong Chen,Jiakang Zhang,Fei Peng,Yunke Bi,Chen Shen,Xu Hou,Daming Zhang,Yaohua Liu,Jing Ai,Shen Zhao
标识
DOI:10.1016/j.toxlet.2014.11.011
摘要
Cancer cells are highly dependent on methionine and cystine (Met–Cys) for survival and proliferation. However, the molecular mechanism is not fully clear. The present study is to investigate the effects of Met–Cys deprivation on glioma cells proliferation. The results showed that Met–Cys double deprivation had synergistic action on elevating ROS level, decreased GSH level and inhibition of glioma cell proliferation. Moreover, both of them deprivation triggered autophagy of glioma cells both in vitro and in vivo. Importantly, Met–Cys double restriction diet inhibited growth of glioma. These results provided a new regulation mechanism of Met–Cys metabolism on affecting glioma cell proliferation, suggesting that targeting Met–Cys metabolism may be a potential strategy for glioma therapy.
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