This chapter contains sections titled: Polymer Supported Oligonucleotide Synthesis: An Overview and History Supports for the Polymer-Supported Synthesis of Oligonucleotides Linkers and Anchor Groups for Solid Phase Oligonucleotide Synthesis Oligonucleotide Synthesis on Soluble Polymer Supports Oligonucleotide Synthesis with Polymer-Supported Reagents Conclusions