The effect of N-acetylcysteine on brain water content and expression of NF-кB in cerebral tissue after experimental intracerebral hemorrhage in rats

Objective To investigate the effect and mechanism of N-acetylcysteine on brain water content perihemotoma after experimental intracerebral hemorrhage in rats. Methods Experimental intracerebral hemorrhage model was maded by injection autologous blood using stereotactic method.NAC was administered immediately after ICH.The expression of NF- к B in cerebral tissues were detected by using immunohistochemistry techniques. At the due time, the rats were killed and brain tissue were removed for measurement of brain water content. Results NF- к B expression and brain water content increased obviously after ICH. Both can be reduced by NAC treatment.There was obvious difference among each intracerebral hemorrhage group and controls(all P0.05) .Conclusions NAC can reduce brain water content after ICH by inhibiting NF- к B and subsequent inflammation.