Growth Differentiation Factor-15 and Cardiovascular Disease

Growth differentiation factor-15(GDF-15) which belongs to the GDF family is a member of TGF-β super family.The previous researches indicated that GDF-15 increased its expression in the condition of rheumatoid arthritis,inflammation,tumor,anemia and so on.During recent years,it was found that increased level of GDF-15 was associated with heart failure(HF),acute coronary syndrome(ACS),idiopathic pulmonary arterial hypertension(IPAH) and other cardiovascular diseases.GDF-15 which provides independent prognostic information in HF and other cardiovascular diseases might be a new promising biomarker.