药代动力学
生物利用度
药理学
计算生物学
药物发现
分配量
药物开发
医学
药品
生物信息学
生物
出处
期刊:Chinese New Drugs Journal
日期:2005-01-01
被引量:128
摘要
Comprehensive retrospective approaches in which the abilities of several methods by which human pharmacokinetic parameters are predicted from preclinical pharmacokinetic data and/or in vitro metabolism data were reviewed.The prediction methods reviewed included those methods from scientific literatures.The prediction of main human pharmacokinetics parameters includes clearance(CL),volume of distribution(V_d),half life(t_(1/2)) and bioavailability using allometric scaling,animal-human proportionality,molecular structural parameters,physicochemical measurements,metabolism data in vitro.Such approaches should find utility in the drug discovery and development processes in the identification and selection of compounds that will possess appropriate pharmacokinetic characteristics in humans for progression to clinical trials.
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