Microgravity centrifugal gas-liquid separation technology with its separation environment is not affected by gravity condition,which is widely used in spacecraft fluid technology,environment control and life support system,etc. In this paper,the numerical simulation has done in the characteristics of centrifugal gas-liquid separation under microgravity environment. When analysing the master-subordinate relations of revolving speed,inlet velocity,air content,viscosity and temperature as they are interacting with each other in the orthogonal experiment,it can be concluded that the separation efficiency is dramatically affected by revolving speed,air content,viscosity and temperature and as the increase of revolving speed,air content and temperature,the separation efficiency gradually decreases. Moreover,inlet velocity has less effect on the separation efficiency. These results are roughly same as that of American ground experiments. The separation efficiency ranges between 92% and 94%. The research conclusions could provide some basic data for Chinese space station ECLSS technology using vapor compression distillation method to further urine separation research.