Immunohistochemical study of NF- κB signal transduction pathway in laryngeal carcinoma

Objective: To explore the expression and significance of IKK, IkB and NF - kB P65 of NF' - ic B signal iransduclii in path-way in laryngeal carcinoma patients. Methods :The expression of IKKa, IicBa.NF-reH P65 was examined by imiminohistocheniical S - P method in laryngeal carcinoma tissues of 40 cases and normal laryngeal tissues of 20 cases. Results -. The expression of IKKa and NF- kB P65 in laryngeal carcinoma tissue was higher compared with normal laryngeal tissue, while the expression of IkHq was lower ( P<0.05). The expression of IKKa and NF'- kB P65 in the carcinoma tisstie with neck lymph node metasiasis was higher than ihai without neck lymph node metastasis, but the expression of IkBq was lower (P<0. 05). Conclusion :NF- kB signal transcluelion path-way may play an important role in occurrence,development and metastasis of laryngeal carcinoma.