Progress of APP secretase and targeted intervention on Alzheimer's disease

α,β and γ secretases are three kinds of key enzymes in processing and metabolizing amyloid precursor protein(APP).Their selective activation of the α secretase or inhibition of β and γ secretase will help reduce the production of β-amyloid protein(Aβ),and may become one of the effective targets to treating AD.This paper aims to make a review on the research development of relevant factors influencing the activity and expression of 3 APP secretases and their targeted intervention in pharmaceutical studies.