From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives

Currently, the generation of peptide ligand libraries where ligand position and identity are varied leading to the discovery of optimal peptide activity and stability is limited. Thus, in this work the synthesis of a p-Dde-Nα-Fmocphenylalanine residue is reported followed by its application in the microwave assisted synthesis of labeled HYNIC Phe8- oxitocine derivatives. Keywords: Microwave, oxytocin, HYNIC, peptide, libraries, conjugate