The Attenuating Effect of Isomaltodextrin on Postprandial Blood Glucose Level in Healthy Human Subjects ―A Randomized, Placebo—controlled, Double—blind Crossover Study―

Objectives To evaluate the effect of isomaltodextrin（IMD）on the postprandial blood glucose level elevation in healthy subjects. Methods A randomized, placebo -controlled, double-blind crossover study was conducted. Fifty subjects ingested a solution containing 50 g glucose with（test diet）or without（control diet）2.5 g IMD. Blood glucose concentrations were measured before and 30, 45, 60, 90, and 120 minutes after ingestion. Forty-five subjects were included in the analysis because five subjects were withdrawn from the study. Results Analysis of all subjects revealed no significant difference between the control and test diets. However, analysis of the subjects with a tendency for increased postprandial blood glucose levels revealed a significant attenuating effect confirmed by measurements of blood glucose and Δblood glucose levels 45 minutes after ingestion. Furthermore, the maximum blood glucose level（Cmax）and ΔCmax following ingestion of the test diet were significantly lower than those following ingestion of the control diet. Conclusions These results suggest that IMD attenuates postprandial blood glucose levels.