driven by the femoral artery and carotid artery for the first time. Furthermore, we demonstrated that the nanofibers have outstanding biocompatibility and can provide a spontaneous microelectronic stimulation effect to improve the growth of nerve cells. Thus, we envision that the high-performance piezoelectric nanofibers may serve as a powerful tool for developing future flexible force-sensitive microelectric devices and generators for applications in bioelectronics and biomedicine.