立体中心
奥西多尔
化学
蒂奥-
催化作用
药物化学
组合化学
全合成
立体化学
有机化学
对映选择合成
作者
Xunbo Lu,Kaiyuan Yang,Xinyu Xu,Siyu Sun,Shanqing Feng,Muhammad Adnan Bashir,Fangpeng Liang,Jie Lin,Guoling Huang
摘要
The construction of the 3-allyl/3-allenyl-3-(thio)oxindole core remains a challenge in organic synthesis. Herein, we report a novel Rh2(esp)2 catalytic Doyle-Kirmse reaction to furnish the oxindole core, bearing unbiased NH as well as a quaternary stereogenic center at the 3-position, in good to excellent yields under mild conditions. These reactions are concise, practical, atom-economic, and highly efficient, and feature a TON of up to 3700. Moreover, a non-radical pathway was observed in this approach.
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