生物
免疫系统
间质细胞
癌细胞
淋巴系统
肿瘤微环境
利基
癌症干细胞
癌症研究
免疫学
干细胞
细胞生物学
癌症
生态学
遗传学
作者
Ada Nowosad,Jean–Christophe Marine,Panagiotis Karras
标识
DOI:10.1016/j.trecan.2023.06.010
摘要
Tumors are heterogeneous ecosystems in which cancer cells coexist within a complex tumor immune microenvironment (TIME). The malignant, stromal, and immune cell compartments establish a plethora of bidirectional cell-cell communication crosstalks that influence tumor growth and metastatic dissemination, which we are only beginning to understand. Cancer cells either co-opt or promote the formation of new blood and lymphatic vessels to cope with their need for nutrients and oxygen. Recent studies have highlighted additional key roles for the tumor vasculature and have identified the perivascular niche as a cellular hub, where intricate and dynamic cellular interactions promote cancer stemness, immune evasion, dormancy, and metastatic spreading. Here, we review these findings, and discuss how they may be exploited therapeutically.
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