DBU Mediated Efficient Synthesis of New N-(furan/thiophene/pyrrole-2-yl- (2-hydroxynaphthalen-1-yl)methyl)acetamides

Abstract: series of N-(furan/thiophene/pyrrole-2-yl-(2-hydroxynaphthalen-1-yl)methyl) acetamide derivatives 4 has been depicted by one-pot three-component synthesis using 2- naphthol 1 with aldehydes 2 and amides 3 in the presence of DBU as a catalyst in ethanol as solvent under reflux condition for 110-120 min. This method has the advantages of good yields, being environmentally friendly, straightforward protocol, short reaction times, and mild reaction conditions.