Photoinduced Copper‐Mediated Difluoroalkylation of Arylsulfonium Salts with XCF2COR

Abstract Photoredox fluoroalkylation has emerged as a powerful method and have unlocked new possibilities in organic chemistry. In this work, the green‐light‐induced copper‐mediated difluoroalkylation of arylsulfonium salts with different XCF 2 COR reagents is described. The reaction proceeded smoothly at ambient temperature under mild conditions and allowed the formation of a variety of difluoroalkylated arenes in good yields. The photocatalyst, visible‐light, and Cu(I) salt played a synergetic role in the reduction of arylsulfonium salt and XCF 2 COR to the respective radical intermediates. This metallophotoredox protocol was applicable to the late‐stage difluoroalkylation of multifunctionalized bioactive molecules, offering opportunities to the discovery of new medicinal agents. The transformation showed advantages of mildness, simple operation, good functional group tolerance, a wide range of substrates, and excellent regioselectivity, which provided an interesting alternative to other difluoroalkylation reactions in terms of structural diversity, selectivity, and availability by the application of arylsulfonium platforms.