Supplementary Material for: High systemic immune-inflammation index, predicting early allograft dysfunction, indicates high 90-day-mortality for acute-on-chronic liver failure after liver transplantation

Introduction: To investigate the relationship between systemic immune-inflammation index (SII) and early allograft dysfunction (EAD) and 90-day-mortality after liver transplantation (LT) in acute-on-chronic liver failure (ACLF). Methods: Retrospective records analysis was done on 114 patients who had LT for ACLF. To identify the ideal SII, the receiver operating characteristic (ROC) curve was used. The incidence of EAD and 90-day-mortality following LT were calculated. The prognostic value of SII was assessed using the Kaplan-Meier technique and the Cox proportional hazards model. Results: The cut-off of SII was 201.5 (AUC=0.728, P<0.001). EAD occurred in 40 (35.1%) patients of the high SII group and 5 (4.4%) patients of the normal SII group, P <0.001. 18(15.8%) deaths occurred in the high SII group and 2(1.8%) deaths occurred in the normal SII group, P =0.008. The multivariate analysis demonstrated that SII ≥201.5, MELD≥27 were independent prognostic factors for 90-day-mortality after LT. Conclusion: SII predicts the occurrence of EAD and is an independent risk factor for 90-day- mortality after LT.