NAD+激酶
烟酰胺单核苷酸
烟酰胺腺嘌呤二核苷酸
烟酰胺
疾病
锡尔图因
Boosting(机器学习)
生物化学
医学
药理学
生物
化学
内科学
生理学
酶
机器学习
计算机科学
作者
Kaitlin A. Freeberg,Ce Ann C Udovich,Christopher R. Martens,Douglas R. Seals,Daniel H. Craighead
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2023-04-17
卷期号:78 (12): 2435-2448
被引量:3
标识
DOI:10.1093/gerona/glad106
摘要
Advancing age and many disease states are associated with declines in nicotinamide adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ abundance with precursor compounds, such as nicotinamide riboside or nicotinamide mononucleotide, has profound effects on physiological function in models of aging and disease. Translation of these compounds for oral supplementation in humans has been increasingly studied within the last 10 years; however, the clinical evidence that raising NAD+ concentrations can improve physiological function is unclear. The goal of this review was to synthesize the published literature on the effects of chronic oral supplementation with NAD+ precursors on healthy aging and age-related chronic diseases. We identified nicotinamide riboside, nicotinamide riboside co-administered with pterostilbene, and nicotinamide mononucleotide as the most common candidates in investigations of NAD+-boosting compounds for improving physiological function in humans. Studies have been performed in generally healthy midlife and older adults, adults with cardiometabolic disease risk factors such as overweight and obesity, and numerous patient populations. Supplementation with these compounds is safe, tolerable, and can increase the abundance of NAD+ and related metabolites in multiple tissues. Dosing regimens and study durations vary greatly across interventions, and small sample sizes limit data interpretation of physiological outcomes. Limitations are identified and future research directions are suggested to further our understanding of the potential efficacy of NAD+-boosting compounds for improving physiological function and extending human health span.
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