皮克林乳液
佐剂
免疫系统
乳状液
金属
水溶液中的金属离子
材料科学
化学
免疫学
化学工程
纳米技术
生物
生物化学
工程类
有机化学
作者
Zhaofei Guo,Fuhua Wu,Yanhua Xu,Xue Tang,Xiejin Xie,Rui Hu,Yangsen Ou,Hongjiao Wei,Lin Ye,Chun‐Ting He,Penghui He,Hairui Wang,Guangsheng Du,Xun Sun
出处
期刊:Nano Research
[Springer Science+Business Media]
日期:2025-01-08
卷期号:18 (3): 94907237-94907237
被引量:1
标识
DOI:10.26599/nr.2025.94907237
摘要
Metal ions play critical roles in many immune processes, and their modulation may open up new forms of vaccine adjuvants. Current vaccines predominantly utilize aluminum salts as adjuvants, but alum has poor ability to induce cellular immunity. Manganese (Mn2+) can activate cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway for amplifying cellular immune responses, but free Mn2+ may cause certain neurotoxicity due to its random in vivo distribution. Herein, Mn2+ is initially biomineralized into human serum albumin nanoparticles (HSA-Mn) to improve the biocompatibility of Mn adjuvants. Then HSA-Mn and alum adjuvants are co-dispersed at the squalene/water interphase, resulting in a bimetallic adjuvant co-stabilized Pickering nanoemulsion (HMANE). Compared to lecithin-stabilized emulsion, HMANE increased the surface roughness by approximately 6-fold and significantly improved its interactions with antigen-presenting cells (APCs). After vaccination, HMANE-adjuvanted inactivated SARS-CoV-2 virus (CorV-HMANE) rapidly induced antibody generation and efficiently activated the STING pathway to produce a stronger cellular immune response. In addition, the abundant memory B and T cells induced by the CorV-HMANE further ensured its long-term protective efficacy for at least 4 months. In conclusion, our study highlights the great potential of Pickering emulsions as metal adjuvant platforms, providing new insight for further adjuvant development.
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