Dual-Phase Antibacterial and Anti-inflammatory Self-Locking Microarray Patches for the Effective Treatment of Acne Vulgaris

) followed by a second phase delivering an anti-inflammatory agent (to mitigate local inflammation). The microarray also features a mechanical interlocking design that secures the patch to the skin for effective adhesion and drug release. Our clinical trials of the dual-phase self-locking microarray demonstrated an 81.4% reduction in acne lesions within 3 days, with complete clearance by day 7. In addition, sebum secretion was reduced by 40.7%, suggesting the therapeutic effectiveness of self-locking microarrays. Findings of this study suggest the potential of self-locking microarrays as a safe and effective transdermal drug-delivery platform for clinical applications.