化学
胺化
催化作用
表面改性
组合化学
有机化学
物理化学
作者
Yueyue Fan,Jingwen Guo,Yifan Bao,Yuan Yao,Huan Meng,Xiaohui Li,Hao Yan,Yuepiao Cai,Xiaodong Bao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-06
卷期号:25 (45): 8162-8167
被引量:1
标识
DOI:10.1021/acs.orglett.3c03480
摘要
We have developed an efficient and green strategy for the synthesis of C2-amino indolin-3-ones and C2-acyloxy indolin-3-ones via KI-catalyzed C(sp3)-H amination and acyloxylation of indolin-3-ones using air as the oxidant. The reaction provides straightforward access to 2-substituted indolin-3-ones by the direct functionalization of indolin-3-ones at the C2 position under mild conditions. Moreover, the conditions enable direct functionalization of a range of complex pharmaceuticals, providing attractive products for medicinal chemistry programs.
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