化学
亚科
受体
内生
神经科学
灵长类动物
药理学
基因
生物化学
心理学
生物
标识
DOI:10.1021/acs.jmedchem.3c02026
摘要
The MAS-related genes (also known as MRGPRs) are a complex family of G protein-coupled receptors initially discovered in sensory neurons. Most of them are orphans, which means that they have no known validated endogenous ligands. Although MRGPRs bear great potential as drug targets, notably in itch and nociception, their study has been hampered by the scarcity or absence of potent and selective ligands, especially for the primate-specific MRGPRX subfamily.
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